Latest News & Publications

Green Ethanol from Biomass? Verenium Looks to Mycosynthetix Fungi

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Mycosynthetix awarded an SBIR grant to work on new Tuberculosis antibiotics
Mycosynthetix, Inc. was recently awarded a Phase I Small Business Innovation Research grant from the National Institutes of Allergy and Infectious Diseases for the project New Tuberculosis Antibiotics from Filamentous Fungi.

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Mevalocidin - novel natural herbicide under development
Mycosynthetix is currently developing Mevalocidin, a new herbicidal natural product from fungal fermentation, for use in organic farming. The US Patent for Mevalocidin (pdf) was issued on July 1st, 2008. Dow AgroSciences LLC of Indianapolis and Mycosynthetix Inc have entered into a royalty-bearing agreement for Mycosynthetix to develop and market this herbicide.

Contact Dr. Cedric Pearce, CEO, at cpearce@mycosynthetix.com for further information.

MRSA (methicillin resistant Staphylococcus aureus)
Mycosynthetix has a number of fungi which are active against this deadly organism. For example see the following article:

Christie Boros, Alissa Dix, Barry Katz, Yelena Vasina and Cedric Pearce: Isolation and Identification of Cissetin - A Setin-like Antibiotic with a Novel cis-Octalin Ring Fusion. Journal of Antibiotics 56, 862-5 (2003).

Influenza
Mycosynthetix has a number of fungi which have shown activity against influenza targets. For example see the following article:

The structure of a new antiviral product isolated from a fungus from the Mycosynthetix collection was recently published: see Emmyguyacins A and B: Unusual Glycolipids from a Sterile Fungus Species that Inhibit the Low-pH Conformational Change of Hemagglutinin A during Replication of Influenza Virus. Christie Boros, Barry Katz, Scott Mitchell, Cedric Pearce, Karra Swinbeck and Debra Taylor, J. Natural Products, 65, 108-114 (2002).

Gene regulation and metabolic diseases
Mycosynthetix fungi have been investigated for low molecular weight gene modulators and a number of interesting compounds found. For example see the following anti-diabetic compound:

A potential anti-diabetic compound has been discovered from a Mycosynthetix fungus and is described in the following publication: Chaowei Zhang, Liang Lin, Belinda Mondie, Scott Mitchell, Arlindo Castelhano, Weizhong Cai and Nils Bergenhem: Leporin B: A Novel Hexokinase II Gene Inducing Agent from an Unidentified Fungus. Bioorganic and Medicinal Chemistry Letters 13 (2003) 1433-1435.

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