Mycosynthetix owns a unique collection of fungi that are the source of a rich variety of fungal metabolites for lead discovery for medicine and agriculture.

Recent Natural Products Presentations by Mycosynthetix

Prof Toru Okuda, President of the Mycological Society of Japan, and Dr. Pearce at the Kabukiza Theatre in the Ginza

Mycosynthetix CEO Dr. Cedric Pearce has given presentations on natural products in Japan and Canada recently. In Japan he spoke at the Mycological Society of Japan Meeting at the Tokyo University of Agriculture and the Microbial Workshop at Tamagawa University. In Canada he presented at the Weed Science Society of America/Canadian Weed Science Society Joint Annual Conference in Vancouver.

A bioherbicide – mevalocidin – and some molecular taxonomy using a barcoding method on the producing taxa. Mycological Society of Japan meeting, Tokyo University of Agriculture, Japan. November, 2013.

Discovery of Anti Cancer Leads from Fungi. Tamagawa University, Japan. Microbial Workshop. November, 2013

The Development of the Fungus-derived Herbicide, Mevalocidin presented at the Weed Science Society of America/Canadian Weed Science Society Joint Annual Conference in Vancouver, Canada. February, 2014.
Abstract: The interest in organic farming and organic produce has seen exponential growth over the past decade. There are few options available for weed control compatible with these products other than manual labor, and new products are needed. Scientists at Mycosynthetix, Inc., in collaboration with colleagues from Dow AgroSciences co-discovered (Gerwick et al, 2013) and subsequently licensed mevalocidin, a novel natural herbicide produced by two of the fungi in the Mycosynthetix fungus library. Mevalocidin is a broad spectrum systemic herbicide that is currently under development for use in organic farming. Two mevalocidin-producing fungi, initially identified as Fusarium (MSX 92917) and Rosellinia (MSX 56446) were studied to optimize the production of the herbicidal activity, and a variety of traditional and non-traditional media were evaluated. A UPLCHRMS method was developed for quantitative analysis of mevalocidin, and this has been used in conjunction with simple plant growth bioassays to measure productivity. The goal of initial experiments was to increase the yield at least 250-fold over that initially observed, and this has been successfully accomplished with yields up to 1000-fold observed in some experiments. We aim to have material ready for field evaluation of mevalocidin in the spring of 2014.

B. C. Gerwick, W. K. Brewster, G. J. deBoer, S. C. Fields, P. R.Graupner, D. Hahn, Cedric J. Pearce, P. R. Schmitzer, J. D. Webster. Mevalocidin: A Novel, Phloem Mobile Phytotoxin from Fusarium DA056446 and Rosellinia DA092917. J. Chem. Ecol., 2013. DOI 10.1007/s10886-013-0238-7

Supported in part by USDA NIFA Phase I SBIR 2012-33610-19523 Pearce (PI) 6/12-5/14