Mycosynthetix owns a unique collection of fungi that are the source of a rich variety of fungal metabolites for lead discovery for medicine and agriculture.

Publications

Recent Presentations

Vincent P. Sica, Mario Figueroa, Huzefa A. Raja, Cedric J. Pearce and Nicholas H. Oberlies. Four peptaibols with a rare threonine residue identified via in situ mass spectrometry monitoring of fungal cultures. Phytochem. 2017.

Raja, Huzefa; Miller, Andrew; Pearce, Cedric; Oberlies, Nicholas. Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community. 2017. J. Nat. Prod 80, pp 2017-

Mariana González-Medina1, John R. Owen, Tamam El-Elimat, Cedric J. Pearce, Nicholas H. Oberlies, Mario Figueroa and Jose L. Medina-Franco. Scaffold Diversity of Fungal Metabolites. Front. Pharmacol. 2017. doi: 10.3389/fphar.2017.00180

Chunwan Lu; Amy V. Paschall; Huidong Shi; Natasha Savage; Jennifer L. Waller; Maria E. Sabbatini; Nicholas H. Oberlies; Cedric Pearce; Kebin Liu
The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion. Journal of the National Cancer Institute 2017 109 (6): djw283
doi: 10.1093/jnci/

Noemi Paguigan, Tamam El-Elimat, Diana Kao, Huzefa Raja, Cedric Pearce, Nicholas Oberlies. Enhanced Dereplication of Fungal Cultures via use of Mass Defect Filtering. J. Antibiotics, 553-561. 2017.

Brooks, W. C., Paguigan, N. D., Raja, H. A., Moy, F. J., Pearce, C.J., Oberlies, N.H. qNMR for profiling the production of fungal secondary metabolites. 2016. Magnetic Resonance in Chemistry.

Mark Grinstaff, Aaron Colby, Cedric Pearce, Nicholas Oberlies. Nanoparticle Drug Delivery Systems for Peritoneal Cancers: A Case Study of the Design, Characterization, and Development of the Expansile Nanoparticle. WIREs Nanomedicine and Nanobiotechnology. 2016

Jiang Wang*, Xiaohua Zhu*, Shamala Kolli, Hongyan Wang, A. Douglas Kinghorn, Cedric J. Pearce, Nicholas H. Oberlies, Mitch A. Phelps. Plasma pharmacokinetics and bioavailability of verticillin A following different routes of administration in mice using liquid chromatography tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2017.

Abeba Zewdu, Gonzalo Lopez, Danielle Braggio, Connor Kenny, Dylan Constantino, Hemant Kumar Bid, Kara Batte, O. Hans Iwenofu, Nicholas H. Oberlies, Cedric J. Pearce, Anne M. Strohecker, Dina Lev, Raphael E. Pollock.. Verticillin A inhibits leiomyosarcoma and malignant peripheral nerve sheath tumor growth via induction of apoptosis. Journal of Clinical & Experimental Pharmacology. 6, 221. 2016.

M. Gonzalez-Medina, F.D. Prieto-Martinez, J.J. Naveja, O. Mendez-Lucio, T. El-Elimat, C.J. Pearce, N.H.Oberlies and J.L. Mendina-Franco. Chemoinformatic expedition of the chemical space of fungal products. Future Medicinal Chemistry. 8, 1399-1412.

Vincent P. Sica, Mario Figueroa, Huzefa A. Raja, Tamam El-Elimat, Blaise A. Darveaux, Cedric J. Pearce and Nicholas H. Oberlies. Optimizing production and evaluating biosynthesis in situ of a herbicidal compound, mevalocidin, from Coniolariella sp. JIMB. 43, 1149-1157. 2016.

Carrie Waterman, Laurent Calcul, Jeremy Beau, Wai Sheung Ma, Matthew D. Lebar, Jacqueline L. von Salm, Charles Harter, Tina Mutka, Lindsay C. Morton, Patrick Maignan, Betty Barisic, Alberto von Olphen, Dennis E. Kyle, Lilian Vrijmoed, Ka-Lai Pang, Cedric J. Pearce and Bill J. Baker. Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery. Medicinal Research Reviews. 36, 144-168. 2016.

Cedric Pearce, Productos Naturales de Origen Microbiano para el tratamiento Enfermedades y Aplicacciones en la Agricultura. UNAM, Mexico City, Mexico. Feb 5, 2016.

*Pearce, Cedric. Uncovering Secrets of the Fungus Pharmacy: Exploring one of the World’s Largest Mycology Libraries; Part 1. Biology. (Part 2. Chemistry. N. H. Oberlies) Chicago. Fusion Natural Products Conference. July 7-11th, 2014.

*Pearce, Cedric. Searching for Anti-Cancer and Anti-Parasite Leads from Filamentous Fungi. Symposium Thinking Big about Small Beings: Recent Advances on Microbial Diversity, Ecology and Biodiscovery. The São Paulo Research Foundation, FAPESP, Biota-FAPESP. FAPESP, Rua Pio XI, Brasil. April 28th – 30th, 2014.

*Pearce, Cedric. Mycosynthetix: a bootstrapped, lifestyle, science-based company. Coleman Foundation Entrepreneurship lecture. University of North Carolina, Greensboro. April, 2014.

*Pearce, Cedric. Mycosynthetix: a bootstrapped, lifestyle, science-based company. Institute for Science Entrepreneurship. Millikin University, Decatur, IL. March, 2014.

Pearce, Cedric. The Development of the Fungus-derived Herbicide, Mevalocidin. Weed Science Society of America/Canadian Weed Science Society joint Annual Conference, Vancouver, Canada. February, 2014.

*Pearce, Cedric. A bioherbicide – mevalocidin – and some molecular taxonomy using a barcoding method on the producing taxa. Mycological Society of Japan meeting, University of Tokyo, Japan. November, 2013.

*Pearce, Cedric. Discovery of Anti Cancer Leads from Fungi. Tamagawa University, Japan. Microbial Workshop. November, 2013

Recent Posters

M. González-Medina, F.D. Prieto-Martínez, J.J. Naveja, O. Méndez-Lucio, T. El-Elimat, C.J.  Pearce, N.H. Oberlies, M. Figueroa, J.L. Medina-Franco. Cheminformatics Analysis of the Chemical Space of Natural Products for Drug Discovery. 3rd Drug Discovery Re-Invented: Emerging Role of Biotechs, Academics and Non-Profits, Fusion Conferences, Fiesta Americana Condesa, Cancun, Mexico, February 21-24, 2017 (Poster).
 
V.P. Sica, H.A. Raja, C.J.  Pearce, N.H. Oberlies. Exploring the Chemical Ecology of Fungi via Secondary Metabolite Distributions. 3rd Drug Discovery Re-Invented: Emerging Role of Biotechs, Academics and Non-Profits, Fusion Conferences, Fiesta Americana Condesa, Cancun, Mexico, February 21-24, 2017 (Poster).
 
J. Rivera-Chávez, T.N. Graf, D.A. Todd, D.H. Foil, H.A. Raja, J.J. Kellogg, A.R. Horswill, N.B. Cech, C.J.  Pearce, N.H. Oberlies. Natural Product Libraries: A Powerful Tool for Discovering New Therapeutic Leads from Fungi. 3rd Drug Discovery Re-Invented: Emerging Role of Biotechs, Academics and Non-Profits, Fusion Conferences, Fiesta Americana Condesa, Cancun, Mexico, February 21-24, 2017 (Poster).

Christopher A. Rice, Beatrice L. Colon, Abdelbasset Ahmed, Kaitlin A. Mettel, Kati Räsänan, Santana A. L. Thomas, Bill J. Baker, Blaise A. Darveaux, Cedric Pearce, David W. Boykin and Dennis E. Kyle . High-throughput screening methods used to fuel the discovery of new chemical structures active against the pathogenic free-living amoeba, Naegleria fowleri and Acanthamoeba spp. ASTMH 65th Annual Meeting. Atlanta November 2016.

*Cedric Pearce. Searching for new leads from one of the world’s largest fungal libraries. NC Ag Biotech Summit. Sept 27-28, 2016. Chapel Hill, NC.

M Jenner, J. Masschelein, Y. Dashti, C Jones, S. Harris, J. Parkhill, C. Pearce, E. Mahenthiralingham, G. L. Challis. Biosynthesis of a “fungal” peptide antibiotic by Burkholderia gladioli. 9th Joint Natural Products Conference 2016, Copenhagen, Denmark, July 24-27. Planta Med 2016; 82(S 01): S1-S381.

Cedric Pearce, Blaise Darveaux, Christopher Rice, Beatrice Colon, Kaitin Mettel, Dennis Kyle, Bill Baker, Nicholas Oberlies. The discovery and evaluation of anti-parasitic metabolites from filamentous fungi. 9th Joint Natural Products Conference 2016, Copenhagen, Denmark, July 24-27.

Oberlies, N.H., J.A. Rivera-Chávez, H.A. Raja, P. Metri, D. Xue, C.J. Pearce. Peptaibols from Trichoderma sp. (MSX70741): Isolation, structure elucidation and biological activity. 9th Joint Natural Products Conference 2016, Copenhagen, Denmark, July 24-27, 2016. (Poster)

Paguigan, N.D., T. El-Elimat, D. Kao, H.A. Raja, C.J. Pearce, N.H. Oberlies. Dereplication of Fungal Secondary Metabolites by UPLC-PDA-HRMS-MS/MS and Mass Defect Filtering. 64th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, San Antonio, TX, June 5-9, 2016.

Soumia Amrine, Cedric Pearce, Nicholas Oberlies. Optimizing the production of fungal epipolythiodioxopiperazine alkaloids facilitated by rapid analysis via the droplet-LMJ-SSP coupled with UPLC-PDA-HRMSMS/MS. 64th ASMS Conference. June 5 – 9, 2016 San Antonio, Texas.

Noemi Paguigan, Cedric Pearce, Nicholas Oberlies. Dereplication of Fungal Secondary Metabolites by UPLC-PDA-HRMS-MS/MS and Mass Defect Filtering. 64th ASMS Conference. June 5 – 9, 2016 San Antonio, Texas.

Vincent Sica, Cedric Pearce, Nicholas Oberlies. Exploring the Chemical Ecology of Fungi via Secondary Metabolite Distribution. 64th ASMS Conference. June 5 – 9, 2016 San Antonio, Texas.

Christopher A. Rice, Beatrice L. Colon, R. Kiplin Guy, Danielle H. Demers, Bill J. Baker, Cedric Pearce, Marc A. Giulianotti, David W. Boykin, Dennis E. Kyle. High throughput screens discover hits to fuel drug discovery for pathogenic free-living amoebae. Keystone Symposia – Drug Discovery for Parasitic Diseases, Lake Tahoe, California. 2016.

Christopher A. Rice, Beatrice L. Colon, R. Kiplin Guy, Danielle H. Demers, Bill J. Baker, Cedric Pearce, Marc A. Giulianotti, David W. Boykin, Dennis E. Kyle. High throughput screens discover hits to fuel drug discovery for pathogenic free-living amoebae.  University of South Florida Research Day 2016

Jeffrey N. Clark, M. Tillotson, J. Carter, B. Hansen, B. Darveaux, S. Mithcell, N. Oberlies and C. Pearce. Novel anthelmintics from filamentous fungi active against filarial worms and soil transmitted helminthes. American Society Tropical Medicine and Hygiene annual meeting, Philadelphia, October 2015.

Vincent P. Sica, Huzefa A. Raja, Tamam El-Elimat, Vilmos Kertesz, Gary J. Van Berkel, Cedric J. Pearce, Nicholas H. Oberlies. Profiling Fungal Cultures in situ via the Droplet-LMJ-SSP Coupled with UPLC-PDA-HRMS-MS/MS. 56th Annual Meeting of the American Society of Pharmacognosy, Copper Mountain, Colorado, July 2015 (Planta Med. 2015).

Cedric Pearce, Blaise Darveaux, Huzefa Raja and Nicolas H. Oberlies. Fungal metabolites as novel anthelmintics against soil-transmitted helminthes. 56th Annual Meeting of the American Society of Pharmacognosy, Copper Mountain, Colorado, July 2015 (Planta Med. 2015).

Sheila Mitchell, Jeffery Clark, Meagan Doss, Jessica Carter, Brenda Hansen, Blaise Darveaux, Nicholas Oberlies and Cedric Pearce. Identification of novel anthelmintics from filamentous fungi. American Association of Veterinary Parasitologists Annual Conference, Boston, MA. July 2015.

Christopher A. Rice, Beatrice L. Colon, Danielle H. Demers, Bill J. Baker, Jim Leahy, Roman Manetsch, Cedric Pearce, Marc A. Giulianotti, David W. Boykin, Dennis E. Kyle. Development of High-Throughput Screens used to Discover Potential Treatments for Naegleria fowleri. USF Health Research Day 2015. Tampa, FL.

Kaur, A., Swanson, S.M., Pearce, C.J., Oberlies, N.H. Natural products from a filamentous fungal isolate of an unidentified species. 55th Annual Meeting of the American Society of Pharmacognosy, Oxford, MS. August 2-6th, 2014. (Planta Med. 2014, 80, 775).

*VanderMolen, KM, BA Darveaux, CJ Pearce, and NH Oberlies. Epigenetic Manipulation of a Filamentous Fungus by the Proteasome-Inhibitor Bortezomib Induces the Production of a New Secondary Metabolite. 65th Southeast Regional Meeting of the American Chemical Society (SERMACS), Atlanta, GA, November 12-16, 2013.

*Paguigan ND, El-Elimat T, Pearce CJ, Oberlies NH. High Resolution MS, MS/MS Database Using LTQ-Orbitrap XL Mass Spectrometer Interfaced with HESI for Dereplication of Fungal Secondary Metabolites. 65th Southeastern Regional Meeting of the American Chemical Society (SERMACS), Atlanta, GA, November 12-16, 2013.

Jeffrey N. Clark; Lee Veasey; Meagan Tillotson; Blaise Darveaux; Nicolas Oberlies, Cedric Pearce. Discovering novel parasiticides from filamentous fungi. American Society Tropical Medicine and Hygiene annual meeting, Washington DC. November 2013.

J.N. Clark1, L. Veasey, M. Tillotson, B. Darveaux, N. Oberlies, C. Pearce. Novel Anti-Filarials from Filamentoud Fungi. American Heartworm Society meeting, New Orleans, September 2013.

*Paguigan, N.D., T. El-Elimat, C. Pearce, and N.H. Oberlies. A High-Resolution MS, MS/MS Database Using LTQ-Orbitrap XL Mass Spectrometer Interfaced with HESI for Dereplication of Fungal Secondary Metabolites. 54th Annual Meeting of the American Society of Pharmacognosy, St. Louis, MO, July 13-17, 2013. (*Planta Med.* *2013**, 79*, 847).

*El-Elimat T., M. Figueroa, T.N. Graf, A.F. Adcock, D.J. Kroll, S.M. Swanson, M.C. Wani, C.J. Pearce, and N.H. Oberlies. Cytotoxic Polyketides from an Unidentified Fungus (MSX45109). 54th Annual Meeting of the American Society of Pharmacognosy, St. Louis, MO, July 13-17, 2013. (*Planta Med.* *2013**, 79*, 850).

*Pearce, C.P., J.N. Clark, L. Veasey, M. Tillotson, B.A. Darveaux, M. Lawrence, and N.H. Oberlies. Discovering Novel Parasiticides Active Against *Brugia pahangi* from Filamentous Fungi. 54th Annual Meeting of the American Society of Pharmacognosy, St. Louis, MO, July 13-17, 2013. (*Planta Med*. *2013*, 79, 850).

*Pearce, C.P., L. Veasey, M. Tillotson, B.A. Darveaux, M. Lawrence, M.S. Figueroa, V.P. Sica, and N.H. Oberlies. Mevalocidin: A Fungus Metabolite with Herbicide Activity and Potential for use in Organic Farming. 54th Annual Meeting of the American Society of Pharmacognosy, St. Louis, MO, July 13-17, 2013. (*Planta Med*. *2013*, 79, 851).

Jeffrey N. Clark1*; Lee Veasey, Meagan Tillotson, Blaise A. Darveaux, Nicolas H. Oberlies, Cedric J. Pearce. Novel anthelmintics and insecticides from filamentous fungi. American Association of Veterinarian Parasitologists Annual Meeting, Chicago. July 2013

*Sica, V.P., M. Figueroa, T. El-Elimat, C.J. Pearce, N.H. Oberlies. A Fungal Derived Herbicide for Organic Farming. 13th Annual Poster and Vendor Night, Central North Carolina Section of the American Chemical Society, Greensboro, NC, March 26, 2013.

*VanderMolen, K.M., H.A. Raja, B.A. Darveaux, C.J. Pearce, N.H. Oberlies. The Effects of Media on the Fungal Metabolome. 13th Annual Poster and Vendor Night, Central North Carolina Section of the American Chemical Society, Greensboro, NC, March 26, 2013.*Awarded 1st Place for Graduate Student Category*

*El-Elimat, T., M. Figueroa, B.M. Ehrmann, N.B. Cech, C.J. Pearce, N.H. Oberlies. A High Resolution MS, MS/MS and UV Library of Fungal Secondary Metabolites as a Dereplication Protocol for Bioactive Natural Products. Annual Poster and Vendor Night, Central North Carolina Section of the American Chemical Society, Greensboro, NC, March 26, 2013.

*Sica, V.P., M. Figueroa, T. El-Elimat, C.J. Pearce, N.H. Oberlies. A Fungal Derived Herbicide for Organic Farming.30th Triangle Chromatography Symposium, McKimmon Center, NC State University, Raleigh, NC, May 16, 2013.

Recent Publications

Chemoinformatic expedition of the chemical space of fungal products. Future Medicinal Chemistry. 2016.

Vincent P. Sica, Mario Figueroa, Huzefa A. Raja, Tamam El-Elimat, Blaise A. Darveaux, Cedric J. Pearce and Nicholas H. Oberlies. Optimizing production and evaluating biosynthesis in situ of a herbicidal compound, mevalocidin, from Coniolariella sp. JIMB. 2016.

Amninder Kaur, Huzefa A. Raja, Blaise A. Darveaux, Wei-Lun Chen, Steven M. Swanson, Cedric J. Pearce and Nicholas H. Oberlies. New diketopiperazine dimer from a filamentous fungal isolate of Aspergillus sydowii. Magn. Reson. Chem. 53, 616-618. 2015

Arlene A. Sy-Cordero, Mario Figueroa, Huzefa A. Raja, Maria Elena Meza Avina, Mitchell P. Croatt, Audrey F. Adcock, David J. Kroll Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies. Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidiun cuboideum. Tetrahedron. 2015.

Fakhouri, L., El-Elimat, T., Hurst, D.P., Reggio, P.H., Pearce, C.J., Oberlies, N.H. and Croatt, M.P. (2015) Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues. Bioorg. Med. Chem. 23, 6993-6999. 2015.

Vincent P. Sica, Huzefa A. Raja, Tamam El-Elimat, Vilmos Kertesz, Gary J. Van Berkel, Cedric J. Pearce and Nicholas H. Oberlies. Dereplicating and Spatial Mapping of Secondary Metabolites from Fungal Cultures In Situ. J. Nat Prod. 2015.

Amy V. Paschall, Dafeng Yang, Xia Li, Jeong-Hyeon Choi, Feiyan Liu, Mario Figueroa, Nicholas H. Oberlies, Cedric Pearce, Wendy B. Bollag, Asha Nayak-Kapoor, Kebin Liu. H3K9 Trimethylation Silences Fas Expression to Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Resistance. J. Immunology. 195, 1868-1882. 2015.

El-Elimat, T., Raja, H.A., Figueroa, M., Swanson, S.M., Falkinham III, J.O., Lucas, D.M., Grever, M.R., Wani, M.C., Pearce, C.J. and Oberlies, N.H. (2015) Sorbicillinoid analogs with cytotoxic and selective anti-Aspergillus activities from Scytalidium album. J. Antibiot. 68, 191-196. (PMC4372511).

El-Elimat, T., Figueroa, M., Raja, H.A., Graf, T.N., Swanson, S.M., Falkinham III, J.O., Wani, M.C., Pearce, C.J. and Oberlies, N.H. (2015) Biosynthetically distinct cytotoxic polyketides from Setophoma terrestris. Eur. J. Org. Chem. 2015, 109-121. (PMC4283843)..

Carrie Waterman, Laurent Calcul, Jeremy Beau, Wai Sheung Ma, Matthew D. Lebar, Jacqueline L. von Salm, Charles Harter, Tina Mutka, Lindsay C. Morton, Patrick Maignan, Betty Barisic, Alberto von Olphen, Dennis E. Kyle, Lilian Vrijmoed, Ka-Lai Pang, Cedric J. Pearce and Bill J. Baker. Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery. Medicinal Research Reviews. Published online. Dec 26, 2014.

Tamam El-Elimata, Huzefa A. Raja, Mario Figueroa, Steven M. Swanson, Joseph Falkinham, David Lucas, Michae Grever, Mansukh C. Wani, Cedric J. Pearce, Nicholas H. Oberlies. Sorbicillinoid analogs with cytotoxic and selective anti-aspergillus activities from Scytalidium album. J Antibiot (Tokyo). 2014 Sep 24. doi: 10.1038/ja.2014.125. [Epub ahead of print]

Karen M. VanderMolen,  Blaise A. Darveaux,  Wei-Lun Chen,  Steven M. Swanson, Cedric J. Pearce  and Nicholas H. Oberlies. Epigenetic manipulation of a filamentous fungus by the proteasome-inhibitor bortezomib induces the production of an additional secondary metabolite. RSC Adv., 2014, 4, 18329-18335.

Waterman, Carrie; Laurent Calcul, Tina Mutka, Dennis E Kyle, Cedric J Pearce, Bill J. Baker. A Potent Antimalarial Trichothecene from Hyphomycetes Species. Tetrahedron Letters. 55, 3989- 3991. 2014.

Laurent Calcul, Carrie Waterman, Wai Sheung Ma, Matthew D. Lebar, Charles Harter, Tina Mutka, Lindsay Morton, Patrick Magian, Alberto Van Olphen, Dennis E. Kyle, Lilian Vrijmoed, Ka-Lai Pang, Cedric Pearce, Bill J. Baker. Screening mangrove endophytic fungi for antimalarial natural products. Marine Drugs 2013, 11, 5036-5050.

Tamam El-Elimat, Mario Figueroa, Brandie M. Ehrmann, Nadja B. Cech, Cedric J. Pearce, and Nicholas H. Oberlies. High-Resolution Ms, Ms/Ms, and UV Database of Fungal Secondary Metabolites as a Dereplication Protocol for Bioactive Natural Products. Journal of Natural Products, 2013, 76, 1709-1716

Mario Figueroa, Huzefa Raja, Joseph O. Falkinham, III, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani , Cedric J. Pearce , and Nicholas H. Oberlies. Peptaibols, Tetramic Acid Derivatives, Isocoumarins, and Sesquiterpenes from a Bionectria sp. (MSX 47401) J. Nat. Prod., 2013, 76, 1007–1015

Tamam El-Elimata, Mario Figueroa, Huzefa A. Raja, Audrey F. Adcock, David J. Kroll, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, Nicholas H. Oberlies, Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species. 2013. Tetrahedron Letters 54, 4300–4302

B. Clifford Gerwick, William K. Brewster, Gerrit J. deBoer, Steve C. Fields, Paul R. Graupner, Donald Hahn, Cedric J. Pearce, Paul R. Schmitzer1, Jeffery D. Webster. Mevalocidin: A Novel, Phloem Mobile Phytotoxin from Fusarium DA056446 and Rosellinia DA092917. J. Chem. Ecol., 2013.

Figueroa, Mario, Tyler N Graf, Sloan Ayers, Audrey F Adcock, David J Kroll, Jilai Yang3, Steven M Swanson, Ulyana Munoz-Acuna, Esperanza J Carcache de Blanco, Rajesh Agrawal, Mansukh C Wani, Blaise A Darveaux, Cedric J Pearce and Nicholas H Oberlies. Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae. Journal of Antibiotics advance online publication 12 September 2012; doi: 10.1038/ja.2012.69

El-Elimat, Tamam, Xiaoli Zhang, David Jarjoura, Franklin J. Moy, Jimmy Orjala, Douglas Kinghorn, Cedric J. Pearce, and Nicholas H. Oberlies. Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents. ACS Med. Chem. Lett. 2012, 3, 645-649

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae. Figueroa, Mario, Tyler N Graf, Sloan Ayers, Audrey F Adcock, David J Kroll, Jilai Yang3, Steven M Swanson, Ulyana Munoz-Acuna, Esperanza J Carcache de Blanco, Rajesh Agrawal, Mansukh C Wani, Blaise A Darveaux, Cedric J Pearce and Nicholas H Oberlies. Journal of Antibiotics advance online publication 12 September 2012; doi: 10.1038/ja.2012.69

Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents. El-Elimat, Tamam, Xiaoli Zhang, David Jarjoura, Franklin J. Moy, Jimmy Orjala, Douglas Kinghorn, Cedric J. Pearce, and Nicholas H. Oberlies. ACS Med. Chem. Lett. 2012, 3, 645−649

Effects of (5Z)-7-Oxozeaenol on MDA-MB-231 Breast Cancer Cells. Acuna, U.M., Wittwer, J., Ayers, S., Pearce, C.J., Oberlies, N.H. and de Blanco, E.J.C. (2012) Anticancer Res. 32, 2415-2421.

Effects of (5Z)-7-Oxozeaenol on the Oxidative Pathway of Cancer Cells. Acuna, U.M., Wittwer, J., Ayers, S., Pearce, C.J., Oberlies, N.H. and De Blanco, E.J.C. (2012) Anticancer Res. 32, 2665-2671.

Cytotoxic Xanthone-Anthraquinone Heterodimers from an Unidentified Fungus of the Order Hypocreales (MSX 17022). Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Susan Matthew, Esperanza J. Carcache de Blanco, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies. Journal of Antibiotics, 2012, 65, 3-8. PMID: 22068158; doi: 10.1038/ja.2011.95

Revisiting the enniatins: a review of their isolation, biosynthesis, structure determination, and biological activities. Sy-Cordero, Arlene, C. Pearce, N. Oberlies (2012). J Antibiot (Tokyo). 2012 Sep 19. doi: 10.1038/ja.2012.71.

The history and chemistry of one of the world’s largest fungal libraries. *Pearce, Cedric. SERMACS 2012. Raleigh NC, November 2012.

Chemical epigenetics induce additional metabolites in a filamentous fungus. Vandermolen, K.M., B. A. Darveaux, C. J. Pearce, N. H. Oberlies. Abstract 791.SERMACS 2012. Raleigh NC, November 2012.

High resolution MS, MS/MS and UV library of fungal secondary metabolites as a a dereplication protocol for bioactive natural products. El-Elimat, T., B. M. Ehrmann, N. B. Cech, C. J. Pearce, N. H. Oberlies. SERMACS 2012. Raleigh NC, November 2012.

Minimizing the Environmental Footprint of Natural Product Extracts. Bukhari, Rabia, Tyler Graf, David Brown, Cedric J. Pearce, and Nicholas H. Oberlies. SERMACS 2012. Raleigh NC, November 2012.

De-inventing the wheel: dereplication tools for natural products research. El-Elimat, Tamam, Brandie M. Ehrmann, Nadja B. Cech, Cedric J. Pearce,* and Nicholas H. Oberlies. 2012 David J Slatkin Symposium, Chicago, October 20, 2012.

Accessing Novel Chemistry from Fungi. *Pearce, Cedric, Nicholas Oberlies, Huzefa Raja and Mario Figueroa Saldivar. 62nd Annual Meeting of the Society for Industrial Microbiology and Biotechnology. Washington DC, August 2012.

Chemical Epigenetics Induce Additional Secondary Metabolites in a Filamentous Fungus. Karen M. VanderMolen, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies. 53rd Annual Meeting of the American Society of Pharmacognosy, New York, NY, July 2012.

Two benzoquinones and one terphenyl compound from an unidentified fungus (MSX 47445). Tamam El-Elimat, Mario Figueroa,Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies. 53rd Annual Meeting of the American Society of Pharmacognosy, New York, NY, July 2012.

DNA barcoding for fungal taxonomy: A primer for the Natural Products Community. Huzefa A. Raja, Danielle N. Hayes, Andrew N. Miller, Blaise A. Darveaux, Cedric J. Pearce, Nicholas H. Oberlies. 53rd Annual Meeting of the American Society of Pharmacognosy, New York, NY, July 2012.

De-inventing the wheel: dereplication tools for natural products research. Tamam El-Elimat, Brandie M. Ehrmann, Nadja B. Cech, Cedric J. Pearce, and Nicholas H. Oberlies. 53rd Annual Meeting of the American Society of Pharmacognosy, New York, NY, July 2012.

Bioactive Constituents from Bionectria sp. (MSX 47401): isolation, structure elucidation and biological activities. Mario Figueroa, Joseph O. Falkinham III, Audrey F. Adcock, David J. Kroll, Huzefa Raja, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies. 53rd Annual Meeting of the American Society of Pharmacognosy, New York, NY, July 2012.

Minimizing the Environmental Footprint of Natural Product Extracts. Bukhari, Rabia, Tyler Graf, David Brown, Cedric J. Pearce, and Nicholas H. Oberlies. 29th Triangle Chromatography Discussion Group Symposium, Raleigh, May, 2012.

Biological and chemical assessment of vermitrasporin, an anti-TB active metabolite from the fungus MSX 105528. Chang Hwa Hwang, Birgit U. Jaki, José G. Napolitano, David C. Lankin, James B. McAlpine, Scott G. Franzblau, Sang Hyun Cho, Cedric J. Pearce, and Guido F. Pauli.  53rd Annual Meeting of the American Society of Pharmacognosy, New York, NY, July 2012.

Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities. Sloan Ayers, Brandie M. Ehrmann, Audrey F. Adcock, David J. Kroll, Esperanza J. Carcache de Blanco, Qi Shen, Steven M. Swanson, Joseph O. Falkinham III, Mansukh C. Wani, Sheila M. Mitchell, Cedric J. Pearce and Nicholas H. Oberlies. Journal of Peptide Science, 2012; doi 10.1002/psc.2425

Cytotoxic Xanthone-Anthraquinone Heterodimers from an Unidentified Fungus of the Order Hypocreales (MSX 17022). Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Susan Matthew, Esperanza J. Carcache de Blanco, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies. Journal of Antibiotics, 2012, 65, 3-8. PMID: 22068158; doi: 10.1038/ja.2011.95

Use of the hollow fiber assay for discovery of novel anticancer agents from fungi. Pearce, C.J., D.D. Lantvit, Q. Shen, D. Jarjoura, X. Zhang, N.H. Oberlies, D.J. Kroll, M.C. Wani, J. Orjala, D.D. Soejarto, N.R. Farnsworth, E.J. Carcache de Blanco, J.R. Fuchs, A.D. Kinghorn, and S.M. Swanson. In Fungal Secondary Metabolism: Methods and Protocols (Methods in Molecular Biology); Keller, N.P. and G. Turner, Eds.; Humana Press/Springer: Totawa, NJ, 2012, in press.

Discovery of potential anticancer agents from aquatic cyanobacteria, filamentous fungi, and tropical plants. Orjala, J., N.H. Oberlies, C.J. Pearce, S.M. Swanson, and A.D. Kinghorn. In Bioactive Compounds from Natural Sources. Second Edition: Natural Products as Lead Compounds in Drug Discovery; Tringali, C., Ed.; Taylor & Francis: London, 2012, pp. 37-63.

Where are the new medicines? The case for terrestrial microorganisms. C. J. Pearce. J Adv Pharm Tech Res 2, 136-137 (2011).

Thielavin B Methyl Ester: A Cytotoxic Benzoate Trimer from an Unidentified Fungus (MSX 55526) from the Order Sordariales. Sloan Ayers, Brandie M. Ehrmann, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies. Tetrahedron Letters, 2011, 52, 5733-5735. doi: 10.1016/j.tetlet.2011.08.125

Resorcylic Acid Lactones with Cytotoxic and NF-kB Inhibitory Activities and Their Structure-Activity Relationships. Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Susan Matthew, Esperanza J. Carcache de Blanco, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies. Journal of Natural Products, 2011, 74, 1126-1131. PMID:21513293; PMCID: PMC3111092; doi: 10.1021/np200062x

Obionin B: An O-Pyranonaphthoquinone Decaketide from an Unidentified Fungus (MSX 63619) from the Order Pleosporales. Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies. Tetrahedron Letters, 2011, 52, 5128-5230. PMID:22025810; PMCID: PMC3183506; doi: 10.1016/j.tetlet.2011.07.102

Cyclodepsipeptides, Sesquiterpenoids, and Other Cytotoxic Metabolites from the Filamentous Fungus Trichothecium sp. (MSX 51320). Arlene A. Sy-Cordero, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies. Journal of Natural Products, 2011, 74, 2137-2142. PMID:21978324; doi: 10.1021/np2004243

Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite. Cherilyn R. Strader, Cedric J. Pearce, and Nicholas H. Oberlies. Journal of Natural Products, 2011, 74, 900-907. PMID:21456524; doi: 10.1021/np2000528

Romidepsin (Istodax, NSC 630176, FR901228, FK228, Depsipeptide): A Natural Product Recently Approved for Cutaneous T-Cell Lymphoma. Karen M. VanderMolen, William McCulloch, Cedric J. Pearce, and Nicholas H. Oberlies. Journal of Antibiotics, 2011, 64, 525-531. PMID: 21587264; PMCID: PMC3163831; doi: 10.1038/ja.2011.35

Dereplication of Fungal Secondary Metabolites. El-Elimat, T., B.M. Ehrmann, N.B. Cech, C.J. Pearce, N.H. Oberlies. 125th North Carolina American Chemical Society Sectional Conference, Raleigh, NC, September 30, 2011. Abstract 113

Cytotoxic Xanthones Isolated from an Unidentified Fungus. Johnston, T.A., S. Ayers, T.N. Graf, A. Adcock, D.J. Kroll, M.C. Wani, C. Pearce, N.H. Oberlies. 125th North Carolina American Chemical Society Sectional Conference, Raleigh, NC, September 30, 2011. Abstract 159

Cytotoxic Fungal Metabolites from a Fusarium sp.. Sy-Cordero, A.A., T.N. Graf, A. Adcock, D.J. Kroll, C. Pearce, M.C. Wani, N.H. Oberlies. 125th North Carolina American Chemical Society Sectional Conference, Raleigh, NC, September 30, 2011. Abstract 180

Revisiting the Enniatins: History, Chemistry and Biological Activities. Sy-Cordero, A.A., T.N. Graf, A. Adcock, D.J. Kroll, C. Pearce, M.C. Wani, N.H. Oberlies. 52nd. Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 30-August 3, 2011.

Effects of (5Z)-7-Oxozeaenol on Prostate and Breast Cancer Cells. Muñoz Acuña, U., J. Wittwer, S. Ayers, C.J. Pearce, N.H. Oberlies, and E.J. Carcache de Blanco. 52nd Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 30-August 3, 2011.

Cytotoxic Epipolythiodioxopiperazine Alkaloids from Fungus Bionectriaceae sp. Strains MSX64546 and MSX70751. Figueroa, M., T.N. Graf, S. Ayers, A.F. Adcock, S.M. Swanson, D.J. Kroll, C.J. Pearce, and N.H. Oberlies. 52nd Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 30-August 3, 2011.

“Peptaibiomics”: Peptaibols from Mycosynthetix Fungus MSX- 70741 (Trichoderma sp.). Ayers, S., B.M. Ehrmann, T.N. Graf, A.F. Adcock, D.J. Kroll, M.C. Wani, C.J. Pearce, and N.H. Oberlies. 52nd Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 30-August 3, 2011.

Chemical Diversity of Secondary Metabolites from Filamentous Fungi, Cyanobacteria, and Tropical Plants vs. Anticancer Drugs. El-Elimat, T., X. Zhang, D. Jarjoura, F.J. Moy, C.J. Pearce, J. Orjala, A.D. Kinghorn, and N.H. Oberlies. 52nd Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 30-August 3, 2011

Isolation & Identification of Antimalarial Compounds from High-Throughput Screening of Niche Microbiota. Laurent Calcul, Carrie Waterman, Jeremy Beau, Wai Ma, Matt Lebar, Jacqueline Salm, Tina Mutka, Patrick Maignan, Raymond Chow, Dennis Kyle, Alberto Van Olphen, Lilian Vrijmoed, Cedric Pearce, Ka-Lai Pang, Bill Baker. The 52nd Annual Meeting of the American Society of Pharmacognosy, San Diego, California July, 2011.

Revisiting the Enniatins: History, Chemistry and Biological Activities. Sy-Cordero, A.A., T.N. Graf, A. Adcock, D.J. Kroll, C. Pearce, M.C. Wani, and N.H. Oberlies. 11th Annual Poster and Vendor Night, Central North Carolina Section of the American Chemical Society, Greensboro, NC, April 12, 2011.

Analysis of the Chemical Diversity of Secondary Metabolites from Filamentous Fungi and Cyanobacteria Compared to Anticancer Drugs. El-Elimat, T., F.J. Moy, C.J. Pearce, J. Orjala, and N.H. Oberlies. 11th Annual Poster and Vendor Night, Central North Carolina Section of the American Chemical Society, Greensboro, NC, April 13, 2011.

Dereplication of Macrocyclic Trichothecenes from Extracts of Filamentous Fungi through UV and NMR Profiles. Arlene A. Sy-Cordero, Tyler N. Graf, Mansukh C. Wani, David J. Kroll, Cedric J. Pearce, and Nicholas H. Oberlies. Journal of Antibiotics, 2010, 63, 539-544. PMID:20648023; PMCID: PMC2946446; doi: 10.1038/ja.2010.77

Microorganisms: Their Role in the Discovery and Development of Medicines. C. Pearce, P. Eckard, I. Gruen-Wollny and F. G. Hansske. in Natural Products Chemistry for Drug Discovery, Royal Society for Chemistry, 2010. Ed. A. D. Buss and M. S. Butler.

Traditional and Modern Medicines from Fungi. Cedric Pearce. International Conference, Folk and Herbal Medicine. Mohanial Sukhadia Univeristy, Udaipur, India. November 2010.

Traditional and Modern Medicines from Fungi. Cedric Pearce. New Developments in Drug Discovery from Natural Products and Traditional Medicines, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar-Punjab, India. November 2010.

Antimalarial Constituents of Microorganisms. Ryan Baker, Anthony Nguyen, Jacqueline Salm, Charles Harter, Matt Lebar, Laurent Calcul, Jeremy Beau, Jaime H. Noguez, Raymond Chow, Tina Mutka, Dennis Kyle, Alberto Van Olphen, Cedric Pearce, Lilian Vrijmoed, Ka-Lai Pang, Bill Baker. The 51st Annual Meeting of the American Society of Pharmacognosy, Tampa, Florida. July, 2010

Discovery of anticancer agents of diverse natural origin. Douglas Kinghorn, Esperanza J. Carcache de Blanco, Hee-Byung Chai, Jimmy Orjala, Norman R. Farnswort, D. Doel Soejarto, Nicholas H. Oberlies, Mansukh C. Wani, David J. Kroll, Cedric J. Pearce, Steven M. Swanson, Robert A. Kramer, William C. Rose, Craig R. Fairchild, Gregory D. Vite, Stuart Emanuel, David Jarjoura and Frederick O. Cope. Pure Appl. Chem., 2009, Vol. 81, No. 6, pp. 1051-1063. doi: 10.1351/PAC-CON-08-10-16

Pharmacognosy Research and Teaching at UCONN, C. Pearce, J. P. N. Rosazza and R. J. Krueger. in American Society of Pharmacognosy History, 2009.

Synthesis and Characterization of Synthetic Analogs of Cinnacidin, a Novel Phytotoxin from Nectria sp.. N. M. Irvine, C. N. Yerkes, P. R. Graupner, R. E. Roberts, D. R. Hahn, C. Pearce and B. C. Gerwick. Pest Manag Sci. 2008 Sep; 64(9):891-9.

Agricultural Lead Compounds

Mevalocidin; A Novel, Phloem-mobile Herbicide with Potential as a Bio-herbicide. B.Clifford Gerwick, Paul Schmitzer, Steve Fields, William K. Brewster, Jeff Webster, Gerrit DeBoer, Terence A. Walsh, David McCaskill, Cedric Pearce, Paul R. Graupne. Natural Products in Pest Management American Chemical Society Fall meeting, Philadelphia, August 2008.

Synthesis and Characterization of Synthetic Analogs of Cinnacidin, a Novel Phytotoxin from Nectria sp. N. M. Irvine, C. N. Yerkes, P. R. Graupner, R. E. Roberts, D. R. Hahn, C. Pearce and B. C. Gerwick. Pest Manag Sci. 2008 Sep; 64(9):891-9.

Novel Agrochemical Leads from Fungi now under Development. Cedric Pearce, The 16th Workshop on Microbial Resources. Fujiyoshida, Japan. 2007.

Discovery, Synthesis and Insecticidal Activity of a Novel Cycloaspeptide. P. Lewer, P. Graupner, D. Hahn, L. Karr, D. Duebelbeis, J. Lira, P. Anzeveno, S. Fields, J. Gilbert and C. Pearce. J Nat. Prod. 69(10):1506-10 (2006).

The Role of LC/MS in the Discovery of a Novel Insecticidal Cycloaspeptide. J. Gilbert, P. Lewer, P. Graupner, D. Duebelbeis, E. Chapin, L. Karr, and C. Pearce. Presented at the 53rd American Society for Mass Spectrometry conference on mass spectrometry and related topics. San Antonio, Texas. June 5th-9th, 2005

Isolation and identification of a novel insecticidal cycloaspeptide P-248. P. Lewer, P. Graupner, J. Gilbert, L. Karr, E. Chapin, D. Duebelbeis, and C. Pearce. Presented at the 46th Annual Meeting of the American Society of Pharmacognosy, University of Oregon. July 26-30, 2005.

Antibiotics and Antiviral Lead Compounds

High throughput screening of fungal cultures for anti tuberculosis activity. Chang Hwa Hwang, Sang Hyun Cho, Cedric Pearce, and Scott G. Franzblau. The 48th Annual Meeting of the American Society of Pharmacognosy, Portland, Maine. July 14-18th, 2007.

Isolation and Identification of the IcosalidesCyclic Peptolides with Selective Antibiotic and Cytotoxic Activities. C. Boros, C. Smith, Y. Vasina, Y. Che, A. Dix, B. Darveaux, and C. Pearce. J Antibiotics 59, 486-494 (2006).

Isolation and Identification of the Antibiotic Icosalide A1. C. Boros, C. Smith,Y. Vasina,Y. Che, A. Dix, B. Darveaux, C. Pearce. The 47th Annual Meeting of the American Society of Pharmacognosy, Arlington, Virginia. August 5-9th, 2006

Isolation and identification of cissetin – a setin-like antibiotic with a novel cis-octalin ring fusion. C. Boros, A. Dix, B. Katz, Y.Vasina and C. Pearce. J. Antibiotics 56, 862-865 (2003).

Emmyguyacins A and B: Glycolipids from a Sterile Fungus Species that Inhibit the Low pH Conformational Change of Hemagglutinin A during Replication of Influenza Virus. C. Boros, B. Katz, S. Mitchell, C. Pearce, K. Swinbank and D. Taylor. J. Nat. Prod. 65, 108-114 (2002)

Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumor necrosis factor alpha-induced human immunodeficiency virus replication. A. Heguy, P. Cai, P. Meyn, D. Houck, S. Russo, R. Michitsch, C. Pearce, B. Katz, G. Bringmann, D. Feineis, D. L. Taylor and A. S. Tyms. Antiviral Chemistry and Chemotherapy 9:149-155. 1998.

Cancer Lead Compounds

Cytotoxic resorcyclic acid lactones from Mycosynthetix fungus MSX-63935. Sloan Ayers, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies. The 51st Annual Meeting of the American Society of Pharmacognosy, Tampa, Florida. July, 2010.

Guangomide A and other bioactive constituents from Trichothecium roseum.Arlene A. Sy-Cordero, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies. The 51st Annual Meeting of the American Society of Pharmacognosy, Tampa, Florida. July, 2010.

Discovery of anticancer agents of diverse natural origin. A. Douglas Kinghorn, Esperanza J. Carcache de Blanco, Hee-Byung Chai, Jimmy Orjala, Norman R. Farnswort, D. Doel Soejarto, Nicholas H. Oberlies, Mansukh C. Wani, David J. Kroll, Cedric J. Pearce, Steven M. Swanson, Robert A. Kramer, William C. Rose, Craig R. Fairchild, Gregory D. Vite, Stuart Emanuel, David Jarjoura and Frederick O. Cope. Pure and Applied Chemistry, 2009. In press. Published online May 5th, 2009.

Novel small molecule inhibitors of glioma cells expressing EGFRVIII. D. Tremblath, N. Oberlies, D. Kroll, C. Pearce, S. Khan and G. Riggins. 15th International Congress of Neuropathology, San Francisco, California. September 9th-16th, 2006.

Gene Modulators

Identification and characterization of mechanistically distinct inducers of γ-globin transcription. J. D. Haley, D. E. Smith, J. Schwedes, R. Brennan, C. Pearce, C. Moore, F. Wang, F. Petti, F. Grosveld, S. M. Jane, C. T. Noguchi, and A. N. Schechter. Biochem. Pharmacol. 66, 1755-1768 (2003)

8-Methyl-Pyridoxatin: A Novel N-Hydroxy Pyridone From Fungus OS-F61800 that Induces Erythropoetin in Human Cells. P. Cai, D. Smith, B. Cunningham, S. Brown-Shimer, B. Katz, C. Pearce, D. Venables and D. Houck. J. Nat. Prod. 6, 397-399. (1999).

Destruxin-A4 Chlorohydrin, a Novel Destruxin from Fungus OS-F68576: Isolation, Structure Determination, and Biological Activity as an Inducer of Erythropoietin. P. Cai, D. Smith, B. Katz, C. Pearce, D. Venables and D. Houck. J. Nat. Prod. 61, 290-293. 1998.

Epolones: Novel Sesquiterpene-Tropolones from Fungus OS-F69284 that Induce Erythropoietin in Human Cells. P. Cai, D. Smith, B. Cunningham, S. Brown-Shimer, B. Katz, C. Pearce, D. Venables and D. Houck. J. Nat. Prod. 61, 791-795. 1998.

New Chemical Entities and Publications of General Interest

High Throughput Fermentations: From Large Numbers to High Yields. Cedric Pearce. Society for Industrial Microbiology, 59th Annual Meeting. San Diego 2008.

Fungal Natural Products with Biological Activity. Meeting: C.Pearce. Leveraging Natural Products for Drug Development, Center for Business Intelligence. Philadelphia, February 2005.

Fungi: A Metabolite for Every Disease. C.Pearce. Society for Industrial Microbiology, 55th Annual Meeting, Los Angeles, CA. August, 2004.

Novel Fungal Metabolites. C. Pearce, B. Darveaux and C. Boros. Society for Biomolecular Screening Annual Meeting, Madrid, Spain. October, 2003.

New Opportunities for Microbial Products in an International Market. C. Pearce. 5th Workshop on Microbial Resources. Tamagawa University, Japan. June 2002.

Mycoepoxydiene Represents a Novel Class of Fungal Metabolites. P. Cai, D. Smith, A. T. Mcphail, E. Krainer, B. Katz, C. Pearce, C. Boros, B. Caceres and D. Houck. Tetrahedron. Letters. 40 (1999) 1479-1482.

Bioactive Fungal Metabolites. C. Pearce. Advances in Applied Microbiology. 44. 1-85. 1997. Academic Press, NY, NY.

Our Involvement with Graduate Education

Industry Immersion Learning, L. Borbye, M. Slocum, A. Woodall, C. Pearce, E. Sale, W. Barrett, L. Clontz, A. Peterson and J. Shaeffer. Wiley-Blackwell 2009.