Selected Publications Involving Mycosynthetix Fungi

Recent Publications

Microorganisms: Their Role in the Discovery and Development of Medicines Cedric Pearce, Peter Eckard, Iris Gruen-Wollny and Friedrich G. Hanske in Natural Product Chemistry for Drug Discovery, 215-244, Antony D Buss and Mark S. Butler editors, RSC Biomolecular Sciences series, The Royal Society of Chemistry, Cambridge, UK. 2010.

Agricultural Lead Compounds

Mevalocidin; A Novel, Phloem-mobile Herbicide with Potential as a Bio-herbicide. B.Clifford Gerwick, Paul Schmitzer, Steve Fields, William K. Brewster, Jeff Webster, Gerrit DeBoer, Terence A. Walsh, David McCaskill, Cedric Pearce, Paul R. Graupne. Natural Products in Pest Management American Chemical Society Fall meeting, Philadelphia, August 2008.

Synthesis and Characterization of Synthetic Analogs of Cinnacidin, a Novel Phytotoxin from Nectria sp. N. M. Irvine, C. N. Yerkes, P. R. Graupner, R. E. Roberts, D. R. Hahn, C. Pearce and B. C. Gerwick. Pest Manag Sci. 2008 Sep; 64(9):891-9.

Novel Agrochemical Leads from Fungi now under Development. Cedric Pearce, The 16th Workshop on Microbial Resources. Fujiyoshida, Japan. 2007.

Discovery, Synthesis and Insecticidal Activity of a Novel Cycloaspeptide. P. Lewer, P. Graupner, D. Hahn, L. Karr, D. Duebelbeis, J. Lira, P. Anzeveno, S. Fields, J. Gilbert and C. Pearce. J Nat. Prod. 69(10):1506-10 (2006).

The Role of LC/MS in the Discovery of a Novel Insecticidal Cycloaspeptide. J. Gilbert, P. Lewer, P. Graupner, D. Duebelbeis, E. Chapin, L. Karr, and C. Pearce. Presented at the 53rd American Society for Mass Spectrometry conference on mass spectrometry and related topics. San Antonio, Texas. June 5th-9th, 2005

Isolation and identification of a novel insecticidal cycloaspeptide P-248. P. Lewer, P. Graupner, J. Gilbert, L. Karr, E. Chapin, D. Duebelbeis, and C. Pearce. Presented at the 46th Annual Meeting of the American Society of Pharmacognosy, University of Oregon. July 26-30, 2005.

Antibiotics and Antiviral Lead Compounds

High throughput screening of fungal cultures for anti tuberculosis activity. Chang Hwa Hwang, Sang Hyun Cho, Cedric Pearce, and Scott G. Franzblau. The 48th Annual Meeting of the American Society of Pharmacognosy, Portland, Maine. July 14-18th, 2007.

Isolation and Identification of the IcosalidesCyclic Peptolides with Selective Antibiotic and Cytotoxic Activities. C. Boros, C. Smith, Y. Vasina, Y. Che, A. Dix, B. Darveaux, and C. Pearce. J Antibiotics 59, 486-494 (2006).

Isolation and Identification of the Antibiotic Icosalide A1. C. Boros, C. Smith,Y. Vasina,Y. Che, A. Dix, B. Darveaux, C. Pearce. The 47th Annual Meeting of the American Society of Pharmacognosy, Arlington, Virginia. August 5-9th, 2006

Isolation and identification of cissetin - a setin-like antibiotic with a novel cis-octalin ring fusion. C. Boros, A. Dix, B. Katz, Y.Vasina and C. Pearce. J. Antibiotics 56, 862-865 (2003).

Emmyguyacins A and B: Glycolipids from a Sterile Fungus Species that Inhibit the Low pH Conformational Change of Hemagglutinin A during Replication of Influenza Virus. C. Boros, B. Katz, S. Mitchell, C. Pearce, K. Swinbank and D. Taylor. J. Nat. Prod. 65, 108-114 (2002)

Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumor necrosis factor alpha-induced human immunodeficiency virus replication. A. Heguy, P. Cai, P. Meyn, D. Houck, S. Russo, R. Michitsch, C. Pearce, B. Katz, G. Bringmann, D. Feineis, D. L. Taylor and A. S. Tyms. Antiviral Chemistry and Chemotherapy 9:149-155. 1998.

Cancer Lead Compounds

Discovery of anticancer agents of diverse natural origin. A. Douglas Kinghorn, Esperanza J. Carcache de Blanco, Hee-Byung Chai, Jimmy Orjala, Norman R. Farnswort, D. Doel Soejarto, Nicholas H. Oberlies, Mansukh C. Wani, David J. Kroll, Cedric J. Pearce, Steven M. Swanson, Robert A. Kramer, William C. Rose, Craig R. Fairchild, Gregory D. Vite, Stuart Emanuel, David Jarjoura and Frederick O. Cope. Pure and Applied Chemistry, 2009. In press. Published online May 5th, 2009.

Novel small molecule inhibitors of glioma cells expressing EGFRVIII. D. Tremblath, N. Oberlies, D. Kroll, C. Pearce, S. Khan and G. Riggins. 15th International Congress of Neuropathology, San Francisco, California. September 9th-16th, 2006.

Gene Modulators

Identification and characterization of mechanistically distinct inducers of γ-globin transcription. J. D. Haley, D. E. Smith, J. Schwedes, R. Brennan, C. Pearce, C. Moore, F. Wang, F. Petti, F. Grosveld, S. M. Jane, C. T. Noguchi, and A. N. Schechter. Biochem. Pharmacol. 66, 1755-1768 (2003)

8-Methyl-Pyridoxatin: A Novel N-Hydroxy Pyridone From Fungus OS-F61800 that Induces Erythropoetin in Human Cells. P. Cai, D. Smith, B. Cunningham, S. Brown-Shimer, B. Katz, C. Pearce, D. Venables and D. Houck. J. Nat. Prod. 6, 397-399. (1999).

Destruxin-A4 Chlorohydrin, a Novel Destruxin from Fungus OS-F68576: Isolation, Structure Determination, and Biological Activity as an Inducer of Erythropoietin. P. Cai, D. Smith, B. Katz, C. Pearce, D. Venables and D. Houck. J. Nat. Prod. 61, 290-293. 1998.

Epolones: Novel Sesquiterpene-Tropolones from Fungus OS-F69284 that Induce Erythropoietin in Human Cells. P. Cai, D. Smith, B. Cunningham, S. Brown-Shimer, B. Katz, C. Pearce, D. Venables and D. Houck. J. Nat. Prod. 61, 791-795. 1998.

New Chemical Entities and Publications of General Interest

High Throughput Fermentations: From Large Numbers to High Yields. Cedric Pearce. Society for Industrial Microbiology, 59th Annual Meeting. San Diego 2008.

Fungal Natural Products with Biological Activity. Meeting: C.Pearce. Leveraging Natural Products for Drug Development, Center for Business Intelligence. Philadelphia, February 2005.

Fungi: A Metabolite for Every Disease. C.Pearce. Society for Industrial Microbiology, 55th Annual Meeting, Los Angeles, CA. August, 2004.

Novel Fungal Metabolites. C. Pearce, B. Darveaux and C. Boros. Society for Biomolecular Screening Annual Meeting, Madrid, Spain. October, 2003.

New Opportunities for Microbial Products in an International Market. C. Pearce. 5th Workshop on Microbial Resources. Tamagawa University, Japan. June 2002.

Mycoepoxydiene Represents a Novel Class of Fungal Metabolites. P. Cai, D. Smith, A. T. Mcphail, E. Krainer, B. Katz, C. Pearce, C. Boros, B. Caceres and D. Houck. Tetrahedron. Letters. 40 (1999) 1479-1482.

Bioactive Fungal Metabolites. C. Pearce. Advances in Applied Microbiology. 44. 1-85. 1997. Academic Press, NY, NY.

Our Involvement with Graduate Education

Industry Immersion Learning, L. Borbye, M. Slocum, A. Woodall, C. Pearce, E. Sale, W. Barrett, L. Clontz, A. Peterson and J. Shaeffer. Wiley-Blackwell 2009.

 
Back to top